Position Details
This position is to assist graduate student Annemarie Carver as we investigate the influence of placental genetics on fetal neurodevelopment in mice. Previous research has shown that placental genetics and function can significantly alter fetal brain development, contributing to the development of neuropsychiatric disorders such as autism spectrum disorder. Despite the established link between the placenta and fetal brain, the specific factors that play a role in this axis are understudied. We are investigating the specific role of placental Insulin-like growth factor 1 (Igf-1) on brain development in mice.
To determine the role of placental Igf-1 in fetal brain development, we utilize multiple methods to either overexpress or knockdown the expression of this gene in the placenta. We then analyze functional and structural changes to the placenta and the fetal brain. Current projects in the lab include assessing placental size and organization, and and assessing cell proliferation in the brain. Frequent techniques used in these experiments are qPCR, ELISA, in situ staining, immunohistochemistry (staining tissue to fluoresce a specific color for specific cells), and stereology (counting cells).
We are seeking a motivated undergraduate to help with these experiments. You can expect to be individually mentored in these concepts and techniques by Annemarie Carver.
Qualifications
STEM major required in good academic standing. Freshmen and sophomores preferred. Attention to detail, clear note-taking, and excitement about science are skills that will greatly help in this position.
Time Commitment
10-12 hours/week
Start Date
Near future
Spring semester
Project Duration
Ongoing or potential to be a continuous position
Compensation
Volunteer
Academic Credit
Apply By
February 28, 2023
How to Apply
Please email Annemarie Carver at annemarie-carver@uiowa.edu with a resume or CV and why you're interested in the position.